Situated near the geographic center of North Carolina, Randolph Community College lies adjacent to the ancient mountains in the area known as the Uwharries. This main campus is located in Asheboro at the McDowell Road exit of Highway 220 Bypass/I73/I74, just south of the interchange with Highways 64 and 49. It is 26 miles south of Greensboro, North Carolina, and Interstate Highways 40 and 85, making it accessible from all parts of the state.

The College is located in an area with a rich tradition. Arts and crafts are preserved both commercially and individually. Today people see the same mountains and streams and pass the same locations of homesteads, mills, churches and schools that were known to the people of 1799. Asheboro, with a population of 25,012, is the home of the North Carolina Zoological Park located off U.S. 64, 5 miles southeast of Asheboro. Countywide, the College draws from a population base of 141,752.